Testsystems - Testing drug candidates
within a living organism"
of unsaturated fatty acids on the homoeostasis
of Atm-/- mice
mechanisms of wound healing, inflammation
and tissue regeneration in mouse strains
with well characterized gene defects (db
/ db, ob / ob; transgene).
the efficiency of gene delivery and other
anti-cancer treatment strategies on pre-established
tumors in nude and SCID mice
of analgesic drug candidates in murine animal
models of inflammatory, mechanical, thermal
and neuropathic pain.
implantation into the rat lumbar spinal
cord for intrathecal administration of analgesic
Functional knock-down of pain-relevant target
proteins within the spinal cord by continuous
delivery of antisense oligonucleotides.
pathomolecular mechanisms and new therapeutic
concepts in inflammatory bowel disease by
colitis mice models
of pathologic secretory processes in mucoviscidosis
by CFTR-knockout mice
Intravital video microscopy to assess the
effects of chemokines and chemokine receptor
antagonists on the transmigration of mononuclear
cells through the microvascular endothelial
model covering the whole live-span of mice
mice for probing aging-related brain disorders
and quantifying human cerebral perfusion
to monitor effects of drugs on tissue perfusion
cerebral neuronal activity in humans during
external stimuli (e.g. pain) to reveal cerebral
function and the influence of drugs ( e.g.
tissue microstructure and neuronal fibers
in brain tissue to reveal any damage of
these structures and the effect of drugs.
of nuclear morphology in brain tumors (surgical
specimen), correlation with survival time
and changes under therapy
Mouse models of hypertension