Institute for rheumatology -
Prof. Dr. Harald Burkhardt

 

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Expertise

  • Diagnosis and therapy of rheumatic diseases
  • Epidemiology and patient care
  • Clinical trials phase IIa-III
  • Obtaining patients material of peripheral blood, synovial fluid and of joint tissues (cell-cultures, DNA, RNA, preparation of cell-suspension out of synovial tissues)
  • Target identification in patient material
  • Examination of biological effects of drugs using synovial cultures and other patient materials

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Resources and Abilities

  • Patient recruitment for obtaining research-relevant materials
  • Recruitment of patients for clinical trials by using exsisting networks
  • Specialized ambulatory care unit for clinical trials (study nurse, investigator,subinvestigators)
  • Research laboratory for cell-cultures
  • Extraction of DNA/RNA
  • Transfection of primary cells
  • Cellisolation out of synoviall tissue by magnetic beads
  • ELISA Spot Assay to measure cytokine secreting cell frequency in synovial tissue
  • RT-PCR and analysis of polymorphisms
  • Flow cytometric analysis

 

 

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Publications

  • Kaltwasser JP.Assessment of the studies. Important recombinant agents in treatment of rheumatoid arthritis. Pharm Unserer Zeit. 2003;32(5):396-403.

  • Moller B, Paulukat J, Nold M, Behrens M, Kukoc-Zivojnov N, Kaltwasser JP, Pfeilschifter J, Muhl H. Interferon-gamma induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes. Rheumatology (Oxford). 2003 Mar;42(3):442-5.

  • Kaltwasser JP, Kessler U, Gottschalk R, Stucki G, Moller B.Effect of recombinant human erythropoietin and intravenous iron on anemia and disease activity in rheumatoid arthritis. J Rheumatol. 2001 Nov;28(11):2430-6.

  • Moller B, Kukoc-Zivojnov N, Kessler U, Rehart S, Kaltwasser JP, Hoelzer D, Kalina U, Ottmann OG.Related Articles, Links Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. Rheumatology (Oxford). 2001 Mar;40(3):302-9.

  • Kaltwasser JP, Wollenhaupt J, Dick W, Raven U, Herholz H.Continuing education as an instrument of medical quality management. Z Rheumatol. 1998 Dec;57(6):437-41.

  • Kaltwasser JP, Kessler U, Gottschalk R, Stucki G, Moller B.Related Articles, Links Effect of recombinant human erythropoietin and intravenous iron on anemia and disease activity in rheumatoid arthritis. J Rheumatol. 2001 Nov;28(11):2430-6.

  • Moller B, Kukoc-Zivojnov N, Kessler U, Rehart S, Kaltwasser JP, Hoelzer D, Kalina U, Ottmann OG.Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. Rheumatology (Oxford). 2001 Mar;40(3):302-9.

  • Kaltwasser JP, Nash P, Gladman D, Rosen CR, Behrens F, Jones P, Wollenhaupt J, Falk FG, Mease P. Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis. Arthritis Rheum. 2004 (in press)

 

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Staff:

  • PD. Dr. med. Burkhard Möller (Group leader)
  • Dr. med. Frank Behrens
  • Matthias Thun
  • Andrea Himsel

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ZAFES-Coordinator:

 

 

 

INSTITUTES AND
MEDICAL CENTERS

 

RHEUMATOLOGY

 

PROF. BURKHARDT

 
 
 

GASTROENTEROLOGY - HEPATOLOGY

 
 

PAEDIATRIC HAEMATOL., ONCOL. & HAEMOSTASEOLOGY

 
 

NEURORADIOLOGY

 
 

CLINICAL PHARMACOLOGY

 
 

GENERAL PHARMACOLOGY &
TOXICOLOGY

 
 

IMMUNE PHARMACOLOGY

 
 

INTERDISCIPLINARY PHARMACOLOGY

 
 

PHARMACEUTICAL TECHNOLOGY

 
 

PHARMACEUTICAL CHEMISTRY

 
 

PHARMACEUTICAL
BIOLOGY

 
 

GEORG SPEYER HAUS

 
 

ORGANIC CHEMISTRY &
CHEMICAL BIOLOGY

 
 

NEUROLOGY

 
 

ANESTHESIOLOGY, INTENSIVE CARE AND
PAIN CONTROL

 
 

OBSTETRICS AND GYNECOLOGY

 
 

DEPARTMENT OF DERMATOLOGY & VENEROLOGY

 
 

CARDIOVASCULAR PHYSIOLOGY

 
 

PEDIATRIC PNEUMOLOGY, ALLERGY AND CYSTIC FIBROSIS

MEDICAL VIROLOGY

ECOLOGY, EVOLUTION AND DIVERSITY, DEPARTMENT AQUATIC ECOTOXICOLOGY

 
 

ORAL, CRANIO-
MAXILLOFACIAL AND
FACIAL PLASTIC SURGERY

 
 

GENERAL AND VASCULAR SURGERY

 
 

CLINICAL NEUROANATOMY

 
 

GENERAL PEDIATRICS

 
 

HAEMATOLOGY, ONCOLOGY

 
 

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY

 
 

BIOCHEMISTRY

 
 

GENERAL PRACTICE

 
 

MPI FOR
BRAIN RESEARCH