Institute for pharmaceutical chemistry -
Prof. Dr. Manfred Schubert-Zsilavecz

 

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Expertise

  • Medicinal Chemistry
  • Synthesis of new PPAR (Peroxisome proliferator-activated receptor) ligands
  • Drug analysis / Pharmacokinetics

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Resources and Abilities

  • HPLC with UV-, Diode-array- and Fluorescence detection
  • GC
  • Routine NMR
  • Electroanalytical Methods (Polarography, Cyclovoltammetry)
  • Mass-spectrometry (EI, CI, FAB)
  • Dissolution test systems

 

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Publications

  • S. Schulte-Löbbert, G. Holoubek, W.E. Müller, M. Schubert-Zsilavecz, M. Wurglics Comparison of the Synaptosomal Uptake Inhibition of Serotonin by St. John’s Wort Products“ Journal of Pharmacy and Pharmacology, 2004, in press

  • P. Pfuhl, U. Kärcher, N. Häring, A. Baumeister, Mona A. Tawab, M. Schubert-Zsilavecz Simultaneous Determination of Niacin, Niacinamide and Nicotinuric Acid in Human Plasma J Pharm and Biomed Anal 2004, in press

  • A. Altmann, D. Poeckl, L. Fischer, M. Schubert-Zsilavecz, D. Steinhilber, O. Werz Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipidmetabolism and peroxide formation in human leukocytes Br J Pharmacol 141(2), 2004, 223-32

  • J.-H. Keller, M. Karas, W.E. Müller, D.A. Volmer, G.P. Eckert, M.A. Tawab, H. Blume, T. Dingermann, M. Schubert-Zsilavecz Determination of Hyperforin in Mouse Brain by Rapid High Performance Liquid Chromatography/Tandem Mass Spectrometry Anal Chem 75(22), 2003, 6084-6088

  • Mona Abdel Tawab, U. Bahr, M. Karas, M. Wurglics, M. Schubert-Zsilavecz Degradation of Ginsenosides in humans after Oral Administration Drug Metabolism and Disposition 31(8), 2003, 1065-1071

  • K. Westerhoff, A. Kaunzinger, M. Wurglics, J. Dressman and Manfred Schubert-Zsilavecz Biorelevant Dissolution Testing of St. John´s Wort Products Journal of Pharmacy and Pharmacology 54, 2002, 1615-1621

  • St. Gebhardt, St. Bihler, M. Schubert-Zsilavecz, S. Riva, D. Monti, L. Falcone, B. Danieli Biocatalytic Generation of Molecular Diversity: Modification of Ginsensoside Rb1 by ß-1,4-Galactosyltransferase and Candida antarctica lipase Helv. chimica acta 85(7), 2002, 1943-1959

  • A. Kaunzinger, A. Baumeister, D. Cuda, N. Häring, Barbara Schug, Henning Blume, K. Raddatz, G. Fischer, M.Schubert-Zsilavecz Determination of 11-keto-boswellic acid in human plasma Journal of Pharmaceutical and Biomedical Analysis 28 (3-4), 2002, 729-739

  • B. Danieli, L. Falcone, D. Monti, S. Riva, S. Gebhardt, M. Schubert-Zsilavecz Regioselective Enzymatic Glycosylation of Natural Polyhydroxylated Compounds.Galactosylation and Glucosylation of Protopanaxatriol Ginsenosides J. Org. Chem.66, 2001, 262-269

  • M. Abdel Tawab, U. Bahr, B. Danieli, S. Gebhardt, M. Karas, S. Riva, and M. Schubert-Zsilavecz ESI MSn as a Tool for Rapid and Sensitive Analysis of Ginsenosides and their Galactosylderivatives Helvetica chimica acta 83(4), 2000, 739-747

 

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Staff:
Work group leader:

  • Prof. Dr. M. Schubert-Zsilavecz (Medicinal Chemistry, Drug analysis
  • Dr. M. Wurglics (Drug analysis, Pharmacokinetics)

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ZAFES-Coordinator:

 

 

 

INSTITUTES AND
MEDICAL CENTERS

 
 

RHEUMATOLOGY

 
 

GASTROENTEROLOGY - HEPATOLOGY

 
 

PAEDIATRIC HAEMATOL., ONCOL. & HAEMOSTASEOLOGY

 
 

NEURORADIOLOGY

 
 

CLINICAL PHARMACOLOGY

 
 

GENERAL PHARMACOLOGY &
TOXICOLOGY

 
 

IMMUNE PHARMACOLOGY

 
 

INTERDISCIPLINARY PHARMACOLOGY

 
 

PHARMACEUTICAL TECHNOLOGY

 

PHARMACEUTICAL CHEMISTRY

 

PROF. KARAS
PROF. SCHUBERT-ZSILAVECZ
PROF. STARK
PROF. STEINHILBER

 

 

 

 

 

PHARMACEUTICAL
BIOLOGY

 
 

GEORG SPEYER HAUS

 
 

ORGANIC CHEMISTRY &
CHEMICAL BIOLOGY

 
 

NEUROLOGY

 
 

ANESTHESIOLOGY, INTENSIVE CARE AND
PAIN CONTROL

 
 

OBSTETRICS AND GYNECOLOGY

 
 

DEPARTMENT OF DERMATOLOGY & VENEROLOGY

 
 

CARDIOVASCULAR PHYSIOLOGY

 
 

PEDIATRIC PNEUMOLOGY, ALLERGY AND CYSTIC FIBROSIS

MEDICAL VIROLOGY

ECOLOGY, EVOLUTION AND DIVERSITY, DEPARTMENT AQUATIC ECOTOXICOLOGY

 
 

ORAL, CRANIO-
MAXILLOFACIAL AND
FACIAL PLASTIC SURGERY

 
 

GENERAL AND VASCULAR SURGERY

 
 

CLINICAL NEUROANATOMY

 

GENERAL PEDIATRICS

HAEMATOLOGY, ONCOLOGY

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY