Institute of pharmaceutical biology

 

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The Institute for Pharmaceutical Biology is made up of Prof. Dr. Rolf Marschalek and Prof. Theo Dingermann, who focus their research upon genomic instability. Prof. Theo Dingermann‘s/HD Dr. Thomas Winckler‘s research group is currently using Dictyostelium discoideum as a model organism to study genomic instability, which is mediated via transposable and retrotransposable elements. The long-term research goals are to gain a better understanding of the transposition mechanisms and their application to the human system. This understanding should lead to the development of novel gene therapeutic vectors with highly specific integration properties. Additional research topics are the use of Dictyostelium as an expression system for recombinant proteins, the establishment of an embryonic toxicity assay, as well as the production and characterization of monoclonal antibodies directed against plant derived, active substances. (Dr. Ilse Zündorf is in charge of the last mentioned project.)

Prof. Dr. Rolf Marschalek’s group is working on high risk acute leukaemia, which is based on chromosomal translocations of the human MLL gene. (Research topics are: the patho-molecular mechanisms of leukemia development, genetic instability, the mechanisms of chromatin and gene regulation, pathobiology and diagnosis of this human disease). All scientific work is carried out in a national and international network of collaborators which includes the NGFN, the „Georg-Speyer-Haus“, the Medicinal Clinic of Frankfurt, along with several other universities and institutions. Furthermore, Prof. Dr. Rolf Marschalek, in collaboration with Prof. Dr. Thomas Klingebiel, established an international diagnosis center which performs genome analysis for leukemia centers in Europe, including Germany (Berlin, Munich, Hanover), the Netherlands (Rotterdam), Austria (Vienna) and Italy (Cagliari, Monza).


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Director:

  • Prof. Dr. Rolf Marschalek

 

Group Leaders:

  • Prof. Dr. Theo Dingermann
  • Prof. Dr. Rolf Marschalek
  • HD Dr. Thomas Winckler

 

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ZAFES-Coordinator:

 

 

 

 

INSTITUTES AND
MEDICAL CENTERS

 
 

RHEUMATOLOGY

 
 

GASTROENTEROLOGY - HEPATOLOGY

 
 

PAEDIATRIC HAEMATOL., ONCOL. & HAEMOSTASEOLOGY

 
 

NEURORADIOLOGY

 
 

CLINICAL PHARMACOLOGY

 
 

GENERAL PHARMACOLOGY &
TOXICOLOGY

 
 

IMMUNE PHARMACOLOGY

 
 

INTERDISCIPLINARY PHARMACOLOGY

 
 

PHARMACEUTICAL TECHNOLOGY

 
 

PHARMACEUTICAL CHEMISTRY

 

PHARMACEUTICAL BIOLOGY

 

PROF. DINGERMANN /
PROF. MARSCHALEK

 
 
 

GEORG SPEYER HAUS

 
 

ORGANIC CHEMISTRY &
CHEMICAL BIOLOGY

 
 

NEUROLOGY

 
 

ANESTHESIOLOGY, INTENSIVE CARE AND
PAIN CONTROL

 
 

OBSTETRICS AND GYNECOLOGY

 
 

DEPARTMENT OF DERMATOLOGY & VENEROLOGY

 
 

CARDIOVASCULAR PHYSIOLOGY

 
 

PEDIATRIC PNEUMOLOGY, ALLERGY AND CYSTIC FIBROSIS

MEDICAL VIROLOGY

ECOLOGY, EVOLUTION AND DIVERSITY, DEPARTMENT AQUATIC ECOTOXICOLOGY

 
 

ORAL, CRANIO-
MAXILLOFACIAL AND
FACIAL PLASTIC SURGERY

 
 

GENERAL AND VASCULAR SURGERY

 
 

CLINICAL NEUROANATOMY

 
 

GENERAL PEDIATRICS

 
 

HAEMATOLOGY, ONCOLOGY

 
 

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY

 
 

BIOCHEMISTRY

 
 

GENERAL PRACTICE

 
 

MPI FOR
BRAIN RESEARCH