Institute of Biochemistry I

 

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It is the intention to elucidate biochemical signatures with relevance to inflammation and hypoxia, thus contributing to Biomedical Research in the area of pathophysiological signal transduction (pathobiochemistry).

Our research interests center on physiological/pathophysiological signal transduction pathways of stress components, which are relevant for the comprehension of human disease. Specifically, we aim at understanding:

  • Inflammation associated with malfunctions in oxygen metabolism
  • Tumor biology linked to macrophage polarization and lipid metabolism
  • Hypoxia / HIF-1α (hypoxia inducible factor-1α) and its role in Biomedicine

Various types of cellular stress such as redox-changes, a lack of oxygen (hypoxia), inflammation and/or cell demise promote cell damage, repair or adaptation towards growth as well as differentiation. Endogenous defence mechanisms balance cell or tissue injury to allow progression towards healing, anti-inflammatory outcomes and cell survival. Understanding cell destructive pathways appears to be of considerable importance in proposing therapeutic means for areas in biomedicine when oxygen supply to cells/tissues becomes limiting (hypoxia/ischemia), during cancer, when macrophage polarization affects tumor biology, and when modulation of innate immunity is required to balance pro- vs. anti-inflammatory signals.


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Director:

  • Prof. Dr. rer. nat. B. Brüne

 

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Staff:

  • Dr. rer. nat. Nathalie Dehne
  • Dr. rer. nat. Emeka Igwe
  • Dr. rer. nat. Axel Johann
  • Dr. rer. nat. Dmitry Namgaladze
  • HD Dr. rer. nat. Andreas von Knethen
  • Dr. rer. nat. Jie Zhou



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ZAFES-Coordiantor:

 

 

 

INSTITUTES AND
MEDICAL CENTERS

 

RHEUMATOLOGY

 
 

GASTROENTEROLOGY - HEPATOLOGY

 
 

PAEDIATRIC HAEMATOL., ONCOL. & HAEMOSTASEOLOGY

 
 

NEURORADIOLOGY

 
 

CLINICAL PHARMACOLOGY

 
 

GENERAL PHARMACOLOGY &
TOXICOLOGY

 
 

IMMUNE PHARMACOLOGY

 
 

INTERDISCIPLINARY PHARMACOLOGY

 
 

PHARMACEUTICAL TECHNOLOGY

 
 

PHARMACEUTICAL CHEMISTRY

 
 

PHARMACEUTICAL
BIOLOGY

 
 

GEORG SPEYER HAUS

 
 

ORGANIC CHEMISTRY &
CHEMICAL BIOLOGY

 
 

NEUROLOGY

 
 

ANESTHESIOLOGY, INTENSIVE CARE AND
PAIN CONTROL

 
 

OBSTETRICS AND GYNECOLOGY

 
 

DEPARTMENT OF DERMATOLOGY & VENEROLOGY

 
 

CARDIOVASCULAR PHYSIOLOGY

 
 

PEDIATRIC PNEUMOLOGY, ALLERGY AND CYSTIC FIBROSIS

MEDICAL VIROLOGY

ECOLOGY, EVOLUTION AND DIVERSITY, DEPARTMENT AQUATIC ECOTOXICOLOGY

 
 

ORAL, CRANIO-
MAXILLOFACIAL AND
FACIAL PLASTIC SURGERY

 
 

GENERAL AND VASCULAR SURGERY

 
 

CLINICAL NEUROANATOMY

 
 

GENERAL PEDIATRICS

 
 

HAEMATOLOGY, ONCOLOGY

 
 

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY

 

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BIOCHEMISTRY

 

PROF. BRUENE

 
 

GENERAL PRACTICE

 
 

MPI FOR
BRAIN RESEARCH